Myocardial imaging with I-123 phenylpentadecanoic acid in normal volunteers
Uptake and washout (..delta..%) of I-123 phenylpentadecanoic acid (IPPA) was studied at rest and following exercise in normal volunteers. I-123 PPA (3-8 mCi) was injected at rest in 6 and at peak exercise in 7 individuals. Gamma camera images were obtained for 60 minutes postinjection (p.i.). Blood samples were analyzed for free I/sup -/ and lipid soluble activity (Bligh and Dyer). Myocardial washout rates and plasma lipid soluble (CHCl/sub 3/) activity were calculated and are presented in this paper. Total blood activity remained unchanged from 10-60 min p.i. and free iodide in plasma was <10% at all times. Heart/lung and heart/liver ratios were also reported observations. The distribution and washout of radioactivity was uniform throughout the myocardium. No adverse reactions were noted in any of the volunteers. This study indicates excellent myocardial images can be obtained from 4 to 40 min. following the injection of IPPA at rest and peak exercise. IPPA may be useful for studying patients with heart disease.
- Research Organization:
- U Texas, Hlth. Sci. Ctr. at Dallas, TX
- OSTI ID:
- 5875255
- Report Number(s):
- CONF-850611-; TRN: 87-039223
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
IODINE 123
DIAGNOSTIC USES
TISSUE DISTRIBUTION
UPTAKE
MONOCARBOXYLIC ACIDS
LABELLING
METABOLISM
MYOCARDIUM
BIOLOGICAL PATHWAYS
SCINTISCANNING
MAN
RETENTION FUNCTIONS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques