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Ozonation of mutagenic and carcinogenic polyaromatic amines and polyaromatic hydrocarbons in water

Journal Article · · Cancer Res.; (United States)
OSTI ID:5875235
; ;
The Salmonella-microsome assay for mutagenesis was used to determine the effect of ozone on the mutagenesis of selected carcinogens and mutagens in water. Short periods of ozonation were shown to completely inactivate the mutagenicity of several polyaromatic amine mutagens including acriflavine, proflavine, and beta-naphthylamine. Selected polyaromatic hydrocarbons were also sensitive to ozonation. Kinetic studies revealed that the mutagenicity of benzo(a)pyrene, 3-methylcholanthrene, and 7,12-dimethylbenz(a)anthracene was destroyed after short periods of ozonation. To correlate loss of mutagenicity with loss of carcinogenicity, two polyaromatic hydrocarbons were treated with ozone, extracted from water with hexane, and tested for carcinogenicity in mice. When 7,12-dimethyl-benz(a)anthracene and 3-methyl-cholanthrene were treated with ozone, there was a substantial reduction in carcinogenicity compared to control groups treated with oxygen alone. However, a small number of tumors developed in the group of animals receiving a hexane extract of ozonated 7,12-dimethylbenz(a)anthracene. This activity may be due to breakdown products of 7,12-dimethylbenz(a)anthracene that are not mutagenic.
Research Organization:
Univ. of Notre Dame, IN
OSTI ID:
5875235
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39:6; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

520200* -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
CARCINOGENS
CHEMICAL REACTIONS
CONTROL
HYDROCARBONS
MAMMALS
MICE
MUTAGENS
ORGANIC COMPOUNDS
OZONIZATION
POLLUTION CONTROL
POLYCYCLIC AROMATIC HYDROCARBONS
RODENTS
VERTEBRATES
WATER POLLUTION CONTROL