Cyclosporin A is an adjuvant in murine IgE antibody responses
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:5875005
Cyclosporin A (CsA) is an undecapeptide fungal metabolite and is generally regarded as a new generation of immunosuppressive drugs. We uncovered a novel immunomodulatory property of CsA as a potent immunologic stimulator in the murine IgE antibody system. The enhancement of IgE responses was observed in mice receiving as few as three daily i.m. injections before Ag priming. Our studies demonstrate the three points listed below. First, CsA potentiates murine IgE responses regardless of Ag specificities in inbred mice. A hierarchy of immunopotentiation by CsA follows the order of low, intermediate, and high IgE responder mice. Second, CsA, when administered along with Ag, exerts a thorough and long lasting impact on the Ag-specific IgE antibody response, and leads to an Ag-specific breakthrough of IgE antibody synthesis in mice rendered tolerant in the IgE antibody system by soluble Ag pretreatment or neonatal IgE treatment. Third, IgE enhancer cells become sensitive to a low dose of irradiation. Two enhancer cellular components are identified, those of the Th cells and B cells, which appear to favor the induction of IgE responses. Understanding the cellular basis of the immunopotentiating effect of CsA will provide further insight into the murine IgE antibody system.
- Research Organization:
- Case Western Reserve Univ., Cleveland, OH (USA)
- OSTI ID:
- 5875005
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 142:12; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GLOBULINS
HEMOCYANIN
IMMUNOGLOBULINS
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
KINETICS
LEUKOCYTES
LOW DOSE IRRADIATION
LYMPHOCYTES
MAMMALS
MATERIALS
METALLOPROTEINS
MICE
ORGANIC COMPOUNDS
PROTEINS
RADIOSENSITIVITY
REACTION KINETICS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
GLOBULINS
HEMOCYANIN
IMMUNOGLOBULINS
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
KINETICS
LEUKOCYTES
LOW DOSE IRRADIATION
LYMPHOCYTES
MAMMALS
MATERIALS
METALLOPROTEINS
MICE
ORGANIC COMPOUNDS
PROTEINS
RADIOSENSITIVITY
REACTION KINETICS
RETICULOENDOTHELIAL SYSTEM
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES