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Management of laryngeal radionecrosis: Animal and clinical experience

Journal Article · · Head Neck Surg.; (United States)
; ;
Radiation necrosis of the laryngeal cartilages is an uncommon complication of radiotherapy for laryngeal carcinoma. It is a devastating process for which there is no one acceptable treatment. Medical management offers only temporary, symptomatic relief, which further necessitates surgical treatment. Surgical management may start with a tracheotomy; however, it often ends with a total laryngectomy. Physiologically, the necrotic cartilages are the source of the problem. It is a general surgical principle that nonviable tissue must be excised to promote healing. Therefore, if the affected laryngeal cartilages were removed, the larynx should heal. Total or near total removal of the thyroid and cricoid cartilages with preservation of the endolaryngeal soft tissues has not been reported in the literature. Theoretically, if the entire cartilaginous framework is removed, there would be no structural support for the airway. We have found using animal models, that submucosal resection of the laryngeal cartilages, leaving the perichondrium and endolaryngeal soft tissues intact can result in a competent airway. Animal and clinical experience will be presented.
Research Organization:
SUNY-Health Sciences Center, Brooklyn (USA)
OSTI ID:
5874128
Journal Information:
Head Neck Surg.; (United States), Journal Name: Head Neck Surg.; (United States) Vol. 11:3; ISSN HNSUD
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
CARCINOMAS
CARTILAGE
CONNECTIVE TISSUE
DISEASES
DOGS
HEALING
INJURIES
LARYNX
MAMMALS
MEDICINE
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
RECOVERY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
TISSUES
VERTEBRATES