Effect of captopril on ERPF in differential diagnosis of hypertension in renal transplant recipients
Impaired function of renal allografts caused by recurrent disease or rejection is often accompanied by hypertension. The etiology of persistent severe hypertension in recipients with good renal function is more difficult to explain. To study this problem, 33 patients with mean arterial pressure (MAP) > 105 mm Hg (at least one year after transplantation) were tested. When compared to a normotensive group, they were found to have increased renal vascular resistance, lower ERPF, and increased renin-angiotensin activity. The effect of Captopril, a converting enzyme inhibitor, was studied to evaluate the role of angiotension. The paper concludes that Captopril test may permit differentiation between native kidney-dependent hypertension (increase in ERPF) and functionally active renal artery stenosis (decline in ERPF) in patients with persistent hypertension and good renal function.
- Research Organization:
- Univ. of Alabama at Birmingham Medical Center, Birmingham, AL
- OSTI ID:
- 5873700
- Report Number(s):
- CONF-850611-; TRN: 87-039312
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ENZYME INHIBITORS
BIOLOGICAL EFFECTS
DIAGNOSTIC USES
UPTAKE
HYPERTENSION
DIAGNOSIS
KIDNEYS
BLOOD FLOW
ISCHEMIA
TRANSPLANTS
ANTIHYPERTENSIVE AGENTS
DYNAMIC FUNCTION STUDIES
LABELLING
VASCULAR DISEASES
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
ORGANS
SYMPTOMS
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques