Gallium-67 transaxial emission tomography in the staging of bronchogenic carcinoma

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5872979

O'Donnell, J K; Go, R T; Feiglin, D F; Mehta, A C; Golish, J A; MacIntyre, W J; O'Donovan, P B; Ross, J S; Emdur, L I

Planar Gallium-67 scintigraphy has proven to be useful in the staging of bronchogenic carcinoma. However, planar images are subject to interpretational difficulties because of overlying soft tissue and bone as well as high body background activity. Transaxial single-photon emission computed tomography (SPECT) provides distinct advantages in overcoming the effects of superimposed tissue and in providing greater image contrast for lesion detection. In order to evaluate Ga-67 transaxial SPECT for the staging of bronchogenic tumors, the authors have performed both planar and SPECT imaging on 37 patients with suspected lung neoplasmas. Studies were obtained 48 hours after I.V. injection of 6-10 mCi Ga-67 citrate using triple-peaked energy settings and medium energy collimation. Planar images of 500K cts. were acquired. SPECT acquisition involved collection of 64 images of the thorax over a 360 degree rotation for a minimum of 10 million total cts. per study. Subsequent computer reconstruction provided images slices in the transverse, coronal and sagittal body planes. SPECT was clearly superior to the planar images, correlating better with other imaging modalities of CT (24 pts) and NMR (9 pts) as well as with clinical results of bronchoscopy. For 7 pts undergoing mediastinoscopy or thoracotomy, there was perfect clinical correlation (6 positive, 1 negative). The authors conclude that Ga-67 SPECT improves upon the accuracy of planar scintigraphy and, in our series to date, it has proven equal to the invasive biopsy staging procedures for evaluating potentially operable bronchogenic tumors.

• Research Organization: Cleveland Clinic Foundation, Cleveland, OH
• OSTI ID: 5872979
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOPSY
BODY
BODY AREAS
CARCINOMAS
CAT SCANNING
CHEST
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
GALLIUM 67
GALLIUM ISOTOPES
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
NEOPLASMS
NMR IMAGING
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TOMOGRAPHY