Effects of temperature and particle size on acid aerosol-induced bronchoconstriction. Report for April 1986-November 1988 (Final)

Technical Report · Sun Jan 01 04:00:00 EST 1989

OSTI ID:5872813

Sheppard, D; Balmes, J; Christian, D

The investigators exposed asthmatic subjects to aerosols of sulfuric acid or saline with varying particle size and osmolarity. Aerosols of unbuffered sulfuric acid at pH 2 did not cause bronchoconstriction in the subjects when inhaled during rest at a sulfate concentration of nearly 3 mg/cm m. Neither osmolarity nor particle size appeared to influence the lack of bronchoconstrictor effect. The investigators also studied whether there was a positive interaction between acidity and low temperature with regard to the potentiation of hypoosmolar aerosol-induced bronchoconstriction. They exposed asthmatic subjects to hypoosmolar aerosols of either sulfuric acid at pH 2 or saline at pH 5.5 at either 7 or 22 deg C. No evidence of a positive interaction between acidity and low temperature was found.

• Research Organization: California Univ., San Francisco, CA (USA). Cardiovascular Research Inst.
• OSTI ID: 5872813
• Report Number(s): PB-89-183065/XAB
• Country of Publication: United States
• Language: English

Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ASTHMA
COLLOIDS
DISEASES
DISPERSIONS
DOCUMENT TYPES
DOSE-RESPONSE RELATIONSHIPS
ENVIRONMENTAL EXPOSURE
FOG
HYDROGEN COMPOUNDS
INHALATION
INORGANIC ACIDS
INTAKE
PARTICLE SIZE
PH VALUE
POLLUTION
PROGRESS REPORT
RESPIRATORY SYSTEM DISEASES
SIZE
SOLS
SULFURIC ACID