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Molecular genetics of chromosome 21 and Down Syndrome

Book ·
OSTI ID:5871327
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This book explores the fundamental nature of Down Syndrome pathology as related to the structure and expression of the genes that are known to be critical in its development. It offers a comprehensive account of the most up-to-date research and an overview of the advances in molecular analysis techniques that are revolutionizing the entire field of chromosome mapping. The book discusses how individual genes in this chromosome have been isolated and studied in both cellular and in vivo models, and chapters cover a variety of specific topics including patterns of recombination according to age and sex seen in genetic linkage mapping of chromosome 21; the possible role of centromere and chromosome structure in nondisjunction; molecular mapping of the down syndrome phenotype; the interferon receptor and inducer genes; and more.
OSTI ID:
5871327
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CONGENITAL MALFORMATIONS
DISEASES
DOWNS SYNDROME
GENETIC MAPPING
HEREDITARY DISEASES
HETEROCHROMOSOMES
HUMAN CHROMOSOME 21
MALFORMATIONS
MAPPING
MOLECULAR BIOLOGY
MUTATIONS
PATHOLOGICAL CHANGES
PHENOTYPE