A genetic analysis of the Werner syndrome region on human chromosome 8p

Journal Article · Tue Jun 01 04:00:00 EDT 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1248· OSTI ID:7160708

Thomas, W; Rubenstein, M; Drayna, D ^[1]; Goto, Makoto ^[2]

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1. Genentech, Inc., South San Francisco, CA (United States)
2. Tokyo Metropolitan Otsuka Hospital, Tokyo (Japan)

Werner syndrome (WRN) is an inherited disorder that produces symptoms of premature aging. This disease is caused by a recessive mutation that has previously been mapped to chromosome 8p. The authors have now used genetic linkage analysis to map the WRN gene relative to chromosome 8 reference loci, to screen candidate genes, and to identify a novel dinucleotide repeat polymorphic marker closely linked to WRN. The WRN locus was mapped relative to the marker loci, PLAT, ANK1, D8S135, and D8S87 of the comprehensive chromosome 8 linkage map. The heregulin (HRG) and the fibroblast growth factor receptor 1 genes (FGFR1) have been mapped to chromosome 8p and are involved in cellular growth. Recombination events were detected between WRN and the HRG and FGFR1 genes, excluding them as candidates for the WRN gene. A polymorphic marker generated in this study, WT251, is linked to WRN at a recombination fraction of 0.006, with a lod score of 16.5. 28 refs., 1 fig., 3 tabs.

• OSTI ID: 7160708
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 16:3; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MARKERS
CHROMOSOMES
GENE REGULATION
GENETIC MAPPING
HUMAN CHROMOSOME 8
HUMAN CHROMOSOMES
LIFE SPAN
MAPPING