Atrial natriuretic peptide in the locus coeruleus and its possible role in the regulation of arterial blood pressure, fluid and electrolyte homeostasis

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90172-8· OSTI ID:5865469

Geiger, H; Sterzel, R B ^[1]; Bahner, U; Heidland, A ^[2]; Palkovits, M ^[3]

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1. Univ. of Erlangen-Nuernberg (West Germany)
2. Univ. of Wuerzburg (West Germany)
3. Semmelweis Univ., Budapest (Hungary)

Atrial natriuretic factor (ANP) is present in neuronal cells of the locus coeruleus and its vicinity in the pontine tegmentum and moderate amount of ANP is detectable in this area by radioimmunoassay. The ANP is known as a neuropeptide which may influence the body salt and water homeostasis and blood pressure by targeting both central and peripheral regulatory mechanisms. Whether this pontine ANP cell group is involved in any of these regulatory mechanisms, the effect of various types of hypertension and experimental alterations in the salt and water balance on ANP levels was measured by radioimmunoassay in the locus coeruleus of rats. Adrenalectomy, as well as aldosterone and dexamethasone treatments failed to alter ANP levels in the locus coeruleus. Reduced ANP levels were measured in spontaneously hypertensive rats, and in diabetes insipidus rats with vasopressin replacement. In contrast to these situations, elevated ANP levels were found in rats with DOCA-salt or 1-Kidney-1-clip hypertension. These data suggest a link between ANP levels in the locus coeruleus and fluid volume homeostasis. Whether this link is causal and connected with the major activity of locus coeruleus neurons needs further information.

• OSTI ID: 5865469
• Journal Information: Life Sciences; (United States), Vol. 49:12; ISSN 0024-3205
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ELECTROLYTES
HOMEOSTASIS
HYPERTENSION
PATHOGENESIS
PEPTIDES
BIOLOGICAL FUNCTIONS
ADRENALECTOMY
ALDOSTERONE
BLOOD PRESSURE
DEXAMETHASONE
INFORMATION NEEDS
NERVE CELLS
RADIOIMMUNOASSAY
ADRENAL HORMONES
ALDEHYDES
ANIMAL CELLS
BIOASSAY
CARDIOVASCULAR DISEASES
CORTICOSTEROIDS
DIAGNOSTIC TECHNIQUES
DISEASES
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KETONES
MEDICINE
MINERALOCORTICOIDS
ORGANIC COMPOUNDS
PREGNANES
PROTEINS
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
SOMATIC CELLS
STEROID HORMONES
STEROIDS
SURGERY
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
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