Biological efficacy of a boronated imidocaptate for neutron capture

Conference · Tue Jan 01 04:00:00 EST 1991 · Transactions of the American Nuclear Society; (United States)

OSTI ID:5864698

Laster, B H; Fairchild, R G ^[1]; Swenson, D ^[2]; Metzger, R

---

1. Brookhaven National Lab., Upton, NY (United States)
2. Karkinos Biochem, Inc., Chandler, AZ (United States)

Neutron capture therapy (NCT) is a binary system that utilizes intracellular {sup 10}B as a target atom for subsequent activation by thermal neutrons according to the {sup 10}B(n,{alpha}){sup 7}Li reaction. In the 1950s, clinical trials of NCT for the treatment of malignant brain tumors were unsuccessful because of (a) the poor penetration of the thermal neutrons and (b) the lack of boron compounds that would give high tumor-to-normal-tissue ratios. The recent development of epithermal neutron beams should permit greater neutron penetration to the depth of the tumor. Additionally, second- and third-generation boron compounds have been synthesized. Many of these are being investigated for their potential use in NCT. Among these are nitroimidazoles. Nitroimidazoles have been of interest as photon radiation sensitizers and have the characteristics of facile tumor penetration and susceptibility to nitroreduction in the tumor. This latter characteristic yields metabolites that bind to cellular macromolecules. Such binding may interfere with DNA repair, and this may be a mechanism in the synergizing activity of the nitroimidazole for alkylating agents or hyperthermia. The DNA repair inhibition, in addition to oxygen enhancement, may play a role in the observed ability of nitroimidazoles to synergize the photon therapy of tumors. The authors took advantage of these features to use this class of compounds as a carrier of boron for NCT.

• OSTI ID: 5864698
• Report Number(s): CONF-910603--
• Conference Information: Journal Name: Transactions of the American Nuclear Society; (United States) Journal Volume: 63
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METAL ISOTOPES
AZOLES
BARYON REACTIONS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
BODY AREAS
BODY TEMPERATURE
BORON 10 TARGET
BOSONS
BRAIN
CENTRAL NERVOUS SYSTEM
CESIUM 137
CESIUM ISOTOPES
DISEASES
DNA REPAIR
EFFICIENCY
ELEMENTARY PARTICLES
ELEMENTS
ENRICHED URANIUM REACTORS
EPITHERMAL NEUTRONS
FACE
FERMIONS
HADRON REACTIONS
HADRONS
HEAD
HETEROCYCLIC COMPOUNDS
HYPERTHERMIA
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
IRRADIATION
IRRADIATION REACTORS
ISOTOPE PRODUCTION REACTORS
ISOTOPES
MASSLESS PARTICLES
MEDICINE
MRR REACTOR
NEOPLASMS
NERVOUS SYSTEM
NEUTRON CAPTURE THERAPY
NEUTRON FLUENCE
NEUTRON REACTIONS
NEUTRON THERAPY
NEUTRONS
NONMETALS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUCLEONS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN
PHOTONS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
REACTORS
REAGENTS
RECOVERY
REPAIR
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
SENSITIZERS
TANK TYPE REACTORS
TARGETS
THERAPY
THERMAL NEUTRONS
THERMAL REACTORS
WATER COOLED REACTORS
WATER MODERATED REACTORS
YEARS LIVING RADIOISOTOPES