Current status of 10B-neutron capture therapy: enhancement of tumor dose via beam filtration and dose rate, and the effects of these parameters on minimum boron content: a theoretical evaluation

Journal Article · Mon Apr 01 04:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90318-9· OSTI ID:5518569

Fairchild, R G; Bond, V P

At least 8 classes of compounds are being evaluated in various laboratories around the world as possible vehicles for the transport of boron to tumors for neutron capture therapy (NCT). A parameter of major importance is the minimum concentration of boron needed in tumors in order to produce improved results in cancer therapy. Calculations are made here of the minimum boron content in tumors necessary for NCT. These estimations are obtained for various neutron beams, on the basis of therapeutic gain produced by the effective dose (absorbed dose X relative biological effect). The effects of repair are considered, in anticipation of having boronated bio-molecules with selective and long- term binding to tumor cells, thus allowing protracted irradiations. Pure epithermal neutron beams (free of significant fast neutron and gamma contamination) are found to offer major advantages, particularly when the effects of repair are included. The various boron compounds being investigated for NCT are evaluated on the basis of necessary minimum boron content in tumor.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 5518569
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:4; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
BARYONS
BEAMS
BORON COMPOUNDS
DISEASES
DOSES
ELEMENTARY PARTICLES
EVALUATION
FAST NEUTRONS
FERMIONS
HADRONS
MEDICINE
NEOPLASMS
NEUTRON BEAMS
NEUTRON CAPTURE THERAPY
NEUTRON THERAPY
NEUTRONS
NUCLEAR MEDICINE
NUCLEON BEAMS
NUCLEONS
PARTICLE BEAMS
RADIATION DOSES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
THERAPY
TUMOR CELLS