Evidence for the presence of angiotensin II-type 1 receptors in brain
Journal Article
·
· Brain Research Bulletin; (USA)
- Neuropsychiatric Research Institute, Fargo, ND (USA)
Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with ({sup 125}I)AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear to exist in the brain, but the type 1 receptor predominates in the small regions of brain where AII binding is highly concentrated. DUP 753 may have a central action involved in its unique antihypertensive effect.
- OSTI ID:
- 5858635
- Journal Information:
- Brain Research Bulletin; (USA), Journal Name: Brain Research Bulletin; (USA) Vol. 25:3; ISSN BRBUD; ISSN 0361-9230
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
ANIMALS
AUTORADIOGRAPHY
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PYRIDINES
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
VASOCONSTRICTORS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
ANIMALS
AUTORADIOGRAPHY
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE PROTEINS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PYRIDINES
RADIOISOTOPES
RATS
RECEPTORS
RODENTS
VASOCONSTRICTORS
VERTEBRATES