In-111 oxine autologous labeled platelets in the diagnosis of kidney graft rejection

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198301000-00003· OSTI ID:5855186

Martin-Comin, J; Roca, M; Grino, J M; Paradell, C; Caralps, C

The usefulness of In-111 oxine labeled autologous platelets in the diagnosis of renal graft rejection was studied. The method is based on imaging of the graft area at 4, 24, 48, and 72 hours after the injection of the labeled cells. The study was done in 31 renal transplant recipients. The control group included four patients with normal renal function without evidence of rejection. No platelet uptake was observed in any of them. The study group included 22 patients with acute rejection which was confirmed histologically in 13. One case of chronic vascular type rejection of the graft tracer uptake was seen. There was a false-positive result due to a perirenal hematoma. In three patients with a non-immunological sudden impairment of renal function, no activity was detected in the graft area. We also evaluated the changes in platelet trapping throughout the study and they seemed to correlate with the response to the antirejection therapy.

• Research Organization: Department of Nuclear Medicine, Hospitalet de Llobregat, Barcelona, Spain
• OSTI ID: 5855186
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 8:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GRAFT-HOST REACTION
DIAGNOSTIC TECHNIQUES
INDIUM 111
DIAGNOSTIC USES
BLOOD PLATELETS
KIDNEYS
LABELLED COMPOUNDS
OXINE
PATIENTS
RADIOISOTOPE SCANNING
TRANSPLANTS
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
QUINOLINES
RADIOISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics