Coupling between regional blood flow and oxygen utilization in the normal human brain. A study with positron tomography and oxygen 15

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Arch. Neurol.; (United States)

DOI:https://doi.org/10.1001/archneur.1983.04050040060010· OSTI ID:5855167

Lebrun-Grandie, P; Baron, J C; Soussaline, F; Loch'h, C; Sastre, J; Bousser, M G

Using the oxygen 15 continuous-inhalation technique and positron emission tomography (PET), the regional cerebral blood flow (rCBF), oxygen extraction fraction (rOEF) and oxygen utilization (rCMRO2) were measured in 19 control subjects. The rCBF and rCMRO2 values, computed for small regions of interest (ROI), were within accepted normal ranges. Larger, more convenient ROI provided values for gray and white matter regions that were, respectively, lower and higher than those found using small ROI. The rOEF values were not affected by the ROI size, but seemed to slightly overestimate real OEF. These findings may be explained by (1) the partial volume effect, and (2) some limitations of the 15O steady state model. The 15O-PET technique therefore provides representative but clinically useful physiological indexes. In addition, our study demonstrated the normal coupling between local oxygen supply and demand.

• Research Organization: Departement de Biologie, Service Hospitalier Frederic-Joliot, Orsay, France
• OSTI ID: 5855167
• Journal Information: Arch. Neurol.; (United States), Vol. 40:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
POSITRON COMPUTED TOMOGRAPHY
BLOOD FLOW
DIAGNOSTIC USES
OXYGEN 15
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
OXYGEN ISOTOPES
RADIOISOTOPES
TOMOGRAPHY
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics