Acute and environmental toxicity studies with hexazinone

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(84)90050-2· OSTI ID:5853271

Kennedy, Jr, G L

The acute toxicity of hexazinone, a herbicide intended for general noncropland areas and selected crop uses (alfalfa and sugarcane), has been evaluated to establish proper handling guidelines and to measure its potential impact on the environment. The material is slightly to moderately toxic when given as a single oral dose; its LD50 in male rats is 1690 mg/kg, in male guinea pigs 860 mg/kg, and in male dogs greater than 3400 mg/kg although in the dog emesis prevented accurate quantitation. When the material is administered intraperitoneally, the LD50 in rats is 530 mg/kg. In both studies, no gross or histologic alterations were apparent. Hexazinone is a moderate to severe eye irritant in the rabbit and produced only mild erythema in rabbit skin at 5278 mg/kg, a dose which did not produce lethality or other clinical signs. Subchronic dermal exposures (10 consecutive doses) to rabbits produced increases in serum alkaline phosphatase and glutamic-pyruvic transaminase at the highest levels tested (680 and 770 mg/kg in two separate experiments) with no effects seen at 150 mg/kg. One-hour inhalation exposure of up to 7.48 mg/liter did not produce mortality in rats.

• Research Organization: E. I. du Pont de Nemours and Company, Inc., Wilmington, DE
• OSTI ID: 5853271
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 4:4; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE PHOSPHATASE
AMINOTRANSFERASES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DOGS
DOSES
ENVIRONMENTAL EFFECTS
ENZYMES
ERYTHEMA
ESTERASES
EYES
FACE
GUINEA PIGS
HEAD
HERBICIDES
HETEROCYCLIC COMPOUNDS
HYDROLASES
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LETHAL DOSES
MAMMALS
NITROGEN TRANSFERASES
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PESTICIDES
PHOSPHATASES
RABBITS
RATS
RODENTS
SENSE ORGANS
SKIN
SYMPTOMS
TRANSFERASES
TRIAZINES
VERTEBRATES