Lumbar cerebrospinal fluid concentrations of somatostatin and neuropeptide Y in multiple sclerosis

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Brain Research Bulletin; (USA)

DOI:https://doi.org/10.1016/0361-9230(90)90229-S· OSTI ID:5853146

Vecsei, L; Csala, B; Widerloev, E E; Ekman, R; Czopf, J; Palffy, G ^[1]

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1. Univ. of Lund (Sweden)

The cerebrospinal fluid (CSF) concentrations of somatostatin and neuropeptide Y were investigated by use of radioimmunoassay in patients suffering from chronic progressive multiple sclerosis. The somatostatin level was significantly decreased in the CSF of patients with multiple sclerosis compared to the control group. The magnitude of this change was more pronounced in patients with severe clinical symptoms of the illness. The CSF neuropeptide Y concentration did not differ from the control values. These findings suggest a selective involvement of somatostatin neurotransmission in multiple sclerosis.

• OSTI ID: 5853146
• Journal Information: Brain Research Bulletin; (USA), Vol. 25:3; ISSN 0361-9230
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CEREBROSPINAL FLUID
CHEMICAL COMPOSITION
NERVOUS SYSTEM DISEASES
PATHOGENESIS
PEPTIDES
RADIOIMMUNOASSAY
SOMATOSTATIN
IODINE ISOTOPES
PATIENTS
BIOASSAY
BIOLOGICAL MATERIALS
BODY FLUIDS
DIAGNOSTIC TECHNIQUES
DISEASES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
ORGANIC COMPOUNDS
PROTEINS
RADIOASSAY
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
TRACER TECHNIQUES
550901* - Pathology- Tracer Techniques