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Radiation chemistry of some platinum-containing radiosensitizers and related compounds

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576425· OSTI ID:5847349
; ;
Oxidation and reduction of cis- and trans-dichlorodiammine platinum II (cis- and trans-PDD), cis-dichlorobis(1-(2-hydroxyethyl)-2 methyl-5 nitroimidazole-N/sup 3/)-platinum II (cis-Flap), and cis-dichlorobis(isopropylamine)-trans-dihydroxyplatinum IV (Chip) have been studied using pulse radiolysis. Spectra corresponding to platinum in various oxidation states have been observed and several rate constants have been obtained. Reduction of all the compounds, except cis-Flap, produces species of a lower oxidation state of platinum which subsequently have both chloride ligands replaced. Ultimately, these products disproportionate. Oxidation of all four compounds consists of production of a higher oxidation state of platinum followed by replacement of chloride ligands and finally disproportionation of the products. Only cis-Flap and Chip could be reduced by oxidized DNA bases. The one-electron reduction potential of cis-Flap was found to be -370 +/- 10 mV. It was not possible to measure the potentials of the other compounds since their ligands were replaced rapidly but it is estimated that the one-electron reduction potentials decrease in the order cis- or trans-Flap > Chip > cis-PDD > trans-PDD.
Research Organization:
Christie Hospital and Holt Radium Institute, Manchester, England
OSTI ID:
5847349
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:1; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600* -- Radiation Chemistry
ABSORPTION SPECTRA
ACCELERATORS
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CESIUM 137
CESIUM ISOTOPES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
COBALT 60
COBALT ISOTOPES
DECOMPOSITION
ELECTRIC POTENTIAL
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
FERMIONS
GAMMA RADIATION
HYDROXYL RADICALS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEPTONS
LIGANDS
LINEAR ACCELERATORS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OXIDATION
PLATINUM COMPOUNDS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOISOTOPES
RADIOLYSIS
RADIOSENSITIVITY EFFECTS
REDUCTION
SPECTRA
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES