Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6408331
Various transition metal complexes containing nitroimidazoles as ligands have been shown to act as radiosensitizers of hypoxic cells in vitro. Sensitization by cis-Pt(II)Cl/sub 2/ (nitroimidazole)/sub 2/ complexes is no greater than that which can be demonstrated by the free nitroimidazole ligand alone. These results differ from those previously described for the compound FLAP where an ER of 2.4 was obtained at a concentration of 50 ..mu..M. The authors report that, even using the same treatment technique, the maximum ER that can be achieved is 1.2. Further, the sensitizing efficiency of FLAP cannot be imporved when cells are kept in contact with the compound for 12 hours in air prior to deoxygenation and irradiation. In contrast, Rh(II) complexes show much greater sensitization than can be obtained with the free ligand and these compounds are in turn more efficient sensitizers than the comparable Pt(II) complexes.
- Research Organization:
- Inst. of Cancer Research, Sutton, England
- OSTI ID:
- 6408331
- Report Number(s):
- CONF-8311204-
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 10:8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AZOLES
CELL KILLING
CHO CELLS
COMPLEXES
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
FIBROBLASTS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
LIGANDS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLATINUM COMPLEXES
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SOMATIC CELLS
TRANSITION ELEMENT COMPLEXES
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AZOLES
CELL KILLING
CHO CELLS
COMPLEXES
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
FIBROBLASTS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
LIGANDS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLATINUM COMPLEXES
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SOMATIC CELLS
TRANSITION ELEMENT COMPLEXES