Gastrointestinal absorption of americium-241 by orally exposed swine: comparison of experimental results with predictions of metabolic models
Two groups of 11-week-old swine (40 miniature and 40 domestic swine) received a single oral administration of 1.9 X 10(8) Bq (5.2 mCi) of /sup 241/Am citrate, and groups of eight animals, four of each type, were killed and sampled at 1, 2, 4, 8, 16, 24, 48, 72, and 96 h and 30 days later. Uptake and excretion patterns of the radioactivity appeared to occur in three phases: rapid uptake, rapid excretion, and then a slower excretion. All animals were systematically dissected, and the eviscerated carcasses were autoclaved for separation of bone and muscle. The predominant site of deposition was bone, and autoclaving had little effect on releasing /sup 241/Am from either bone or muscle. The maximum fractional gastrointestinal absorption of 1.1 X 10(-3) occurred 8 h after radionuclide administration. The tissue distribution data suggest partitions of 50, 20, and 30%, for bone, liver, and other soft tissues, respectively. Two metabolic models were evaluated: a modified Mewhinney-Griffith model and the ICRP 30 model to compare the biological data with model predictions. All models underestimated the actual early time data, but the fits to the experimental results were better at later times.
- Research Organization:
- Oak Ridge Associated Universities, TN
- OSTI ID:
- 5845455
- Journal Information:
- Radiat. Res.; (United States), Vol. 112:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AMERICIUM 241
INTESTINAL ABSORPTION
TISSUE DISTRIBUTION
SKELETON
RADIONUCLIDE KINETICS
BIOLOGICAL MODELS
COMPARATIVE EVALUATIONS
METABOLISM
ORAL ADMINISTRATION
SWINE
ABSORPTION
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM ISOTOPES
ANIMALS
BODY
DISTRIBUTION
DOMESTIC ANIMALS
HEAVY NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells