Compartmental analysis of benzo(a)pyrene toxicokinetics

Conference · Thu May 01 04:00:00 EDT 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5206202

Bevan, D R; Weyand, E H

A multicompartmental model to describe quantitatively the toxicokinetics of benzo(a)pyrene (B(a)P) was developed using SAAM (Simulation, Analysis and Modeling). (/sup 3/H)-B(a)P dissolved in triethylene glycol was administered intratracheally to male Sprague-Dawley rats, and amounts of (/sup 3/H) were quantified in various tissues at selected times up to 6 hr after administration. Elimination of (/sup 3/H)-B(a)P and/or metabolites from lungs was biphasic, with half-times of 5.3 min. and 116 min. (/sup 3/H)-B(a)P and/or metabolites were subsequently distributed primarily to liver and carcass (muscle, bones, fat, skin and associated blood). Carcass contained about 20% of administered (/sup 3/H) at 6 hr after administration, and agreement between the model and experimental data required that the carcass be modeled as two compartments, one with rapid and one with slow exchange. Approximately 50% of the administered dose was excreted in feces in 6 hr and only 2% appeared in urine. Enterohepatic circulation was accounted for in the model. The model was then used to predict amounts of (/sup 3/H)-B(a)P and/or metabolites which would be excreted into bile in animals with bile duct cannulas, and good agreement between the model and data was observed.

• Research Organization: Virginia Polytechnic Institute, Blacksburg
• OSTI ID: 5206202
• Report Number(s): CONF-8606151-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:6
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CLEARANCE
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
EXCRETION
FAT CELLS
FECES
GLANDS
HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
LUNG CLEARANCE
LUNGS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
MUSCLES
ORGANIC COMPOUNDS
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
SKELETON
SKIN
SOMATIC CELLS
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
URINE
VERTEBRATES
WASTES