Histomorphologic changes induced by methyl isocyanate in lungs in rats and rabbits

Journal Article · Fri May 01 00:00:00 EDT 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01616715· OSTI ID:5844525

Pant, S C; Srivastava, R K; Vijayaraghavan, R

Methyl isocyanate is a highly reactive compound and its biological effects are due to its reactivity as acylating agent. It causes corrosive damage to tissue exposed by inhalation and topical application. The available literature contains information on the gross morphological changes induced by MIC on the lungs. Discolored lungs with tissue necrosis and mottled red to reddening of entire lung surface have been reported following exposure to MIC. However, the effects of varying concentrations of MIC on the lung architecture has apparently not been studied in detail. This could delineate the possible mechanism of damage caused to lungs. The present study was undertaken with this aim in view.

• Research Organization: Defense Research and Development Establishment, Gwalior, India
• OSTI ID: 5844525
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 38:5; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
EPITHELIUM
HISTOLOGY
ISOCYANATES
LUNGS
MAMMALS
MORPHOLOGICAL CHANGES
ORGANS
RABBITS
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES