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In-vivo measurement of lithium in the brain and other organs

Patent ·
OSTI ID:5843836
; ; ; ;
The lithium used clinically and distributed in organs such as the brain or kidney of humans and other exhaling animals is determined in-vivo by means of neutron radiation and measuring in the exhaled air elemental tritiated hydrogen released from the tritium reaction by the reaction /sub 6/Li(n,a)T. The tritium atoms so released are transformed in part in the surrounding aqueous solution to form gaseous tritiated hydrogen which has a small solubility in body tissues and liquids and thus appears quickly in the breath. After a recipient fasts and is irradiated with neutrons, the air exhaled in the breath for a given time after irradiation is captured and processed to remove water, isolate hydrogen and measure the tritiated hydrogen with a gaseous organ-methane counter.
Assignee:
The United States of America as represented by the Department of Energy
Patent Number(s):
US 4556068
OSTI ID:
5843836
Country of Publication:
United States
Language:
English

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Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALI METALS
BARYON REACTIONS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BODY
BRAIN
BREATH
CENTRAL NERVOUS SYSTEM
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
ELEMENTARY PARTICLES
ELEMENTS
EXCRETION
EXHALATION
FERMIONS
HADRON REACTIONS
HADRONS
HYDROGEN ISOTOPES
IN VIVO
IRRADIATION
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
LITHIUM
LITHIUM 6 TARGET
MEDICINE
METALS
NERVOUS SYSTEM
NEUTRON REACTIONS
NEUTRONS
NUCLEAR MEDICINE
NUCLEAR REACTIONS
NUCLEI
NUCLEON REACTIONS
NUCLEONS
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RETENTION
TARGETS
TISSUES
TRITIUM
TRITIUM COMPOUNDS
YEARS LIVING RADIOISOTOPES