Radiation-induced osteochondroma-like lesion in young rat radius

Journal Article · Sun Dec 01 04:00:00 EST 1985 · Clin. Orthop. Relat. Res.; (United States)

DOI:https://doi.org/10.1097/00003086-198512000-00038· OSTI ID:5843072

Delgado, E; Rodriguez, J I; Serrada, A; Tellez, M; Paniagua, R

To investigate the effects of radiation on the perichondrial groove of Ranvier in osteochondroma development, the external surface of the distal growth plate of the radius in both forelimbs of 30 ten-day-old rats was exposed to a single low dose of radiation (150 r), which was focused on the perichondrial groove. This induced the formation of a chondrocyte nest at the proximal external edge of the growth plate (five to nine days after irradiation). With advancing longitudinal growth of the bone, the chondrocyte nest occupied a diaphyseal position. At nine to 11 days the chondrocyte nest underwent endochondral ossification. At 13-15 days, this osteochondroma-like lesion began to regress with the disappearance of the chondrocyte nest. After 19-21 days, only an irregularly thickened cortical bone remains at the osteochondroma site. Although the possible role of the growth plate subjacent to the irradiated perichondrial groove must be taken into account, the continuity between the perichondrial groove and the osteochondroma, which is separated from the growth plate by the periosteal ring (bone bark), suggests that the perichondrial groove was involved in osteochondroma-like lesion development.

• OSTI ID: 5843072
• Journal Information: Clin. Orthop. Relat. Res.; (United States), Journal Name: Clin. Orthop. Relat. Res.; (United States) Vol. 201; ISSN CORTB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DOSES
EXPERIMENTAL NEOPLASMS
LIMBS
MAMMALS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RATS
RODENTS
SKELETON
VERTEBRATES