ACTH and. cap alpha. -melanotropin in central temperature control
Adrenocorticotropin (ACTH) and ..cap alpha..-melanotropin (..cap alpha..-MSH) occur in brain tissue known to be important to temperature control. These peptides cause hypothermia if they are injected centrally in sufficient doses, but they do not act on the central set point of temperature control. Instead they appear to inhibit central pathways for heat conservation and production. In addition to their hypothermic capability, these peptides are antipyretic when given centrally in doses that have no effect on normal body temperature. ACTH has previously been associated with fever reduction in both clinical and experimental studies, and it may be that endogenous central ACTH is important for limitation of maximal fever. The hypothermic and antipyretic effects of ACTH do not depend on stimulation of the adrenal cortex because they are also observed in adrenalectomized rabbits. Nor is the antipyretic effect limited to the rabbit inasmuch as a comparable effect has been demonstrated in the squirrel monkey. The two peptides may be involved in central mediation of normal thermoregulation and fever, perhaps limiting the febrile response and other rises in body temperature by acting as neurotransmitters or neuromodulators in central thermoregulatory pathways.
- Research Organization:
- Univ. of Texas Health Science Center, Dallas
- OSTI ID:
- 5841521
- Journal Information:
- Fed. Proc.; (United States), Vol. 40:13; Conference: Newer putative central neurotransmitters: roles in thermoregulation, Atlanta, GA, USA, 14 Apr 1981
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
NEUROREGULATORS
BIOCHEMICAL REACTION KINETICS
THERMOREGULATION
BIOLOGICAL PATHWAYS
ACTH
ANTIPYRETICS
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
HYPOTHALAMUS
NERVE CELLS
PEPTIDES
RABBITS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONTROL
DATA
DRUGS
HORMONES
INFORMATION
KINETICS
MAMMALS
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
REACTION KINETICS
SOMATIC CELLS
TEMPERATURE CONTROL
VERTEBRATES
560205* - Thermal Effects- Vertebrates- (-1987)
550100 - Behavioral Biology