Subacute cadmium intoxication in jewelry workers: an evaluation of diagnostic procedures

Journal Article · Tue May 01 04:00:00 EDT 1979 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1979.10667392· OSTI ID:5841123

Baker, Jr, E L; Peterson, W A; Holtz, J L; Coleman, C; Landrigan, P J

An outbreak of cadmium intoxication in a jewelry factory provided an opportunity for evaluating the usefulness of diagnostic procedures used to evaluate human cadmium toxicity. Blood cadmium levels in workers exposed to cadmium were higher (.93 micrograms/100 ml vs .38 micrograms/100 ml) than in unexposed workers. A dose-response relationship was noted between blood cadmium level and symptom prevalence in four symptoms (dyspnea, chest pain, dysuria, and dizziness). Segmental hair analysis revealed highest cadmium levels (up to 19 micrograms/gm) in segments formed prior to cadmium exposure, suggesting that extrinsic contamination was the primary source of cadmium in the hair. Beta-2-microglobulin levels were within normal limits. No significant renal or pulmonary dysfunction was noted. Symptoms ceased after a cadmium-containing brazing alloy used in jewelry production was replaced, yet urine cadmium levels remained persistently elevated in four workers. Blood cadmium determinations were found to be useful in evaluating symptoms potentially related to cadmium intoxication.

• Research Organization: Bureau of Epidemiology, Atlanta, GA
• OSTI ID: 5841123
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 34:3; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY FLUIDS
CADMIUM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
MATERIALS
METALS
OCCUPATIONAL DISEASES
TOXICITY
URINE
WASTES