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The caffeine breath test and caffeine urinary metabolite ratios in the Michigan cohort exposed to polybrominated biphenyls: A preliminary study

Journal Article · · Environmental Health Perspectives; (USA)
DOI:https://doi.org/10.1289/ehp.9089175· OSTI ID:5840096
; ; ;  [1]; ;  [2]; ; ;  [3]
  1. Univ. of Chicago, IL (USA)
  2. Michigan Dept. of Public Health, Lansing (USA)
  3. Univ. of Toronto, Ontario (Canada)
+ Show Author Affiliations

A field biochemical epidemiology study was conducted using the Michigan cohort consisting of 51 rural residents exposed to polybrominated biphenyls (PBB). The study had three major objectives: (a) to determine the serum half-life of the major PBB congener, hexabromobiphenyl (HBB), in the human, (b) to determine if the PBB-exposed subjects had elevated cytochrome P-450I function as determined by the caffeine breath test (CBT) and the caffeine urinary metabolite ratio (CMR), and (c) to determine the applicability of the CBT and CMR in field studies. PBB serum levels were detected in 36 of the 51 PBB-exposed subjects. The serum half-life of HBB was determined by comparing the current serum HBB values to the subject's previous serum values obtained 5 to 8 years earlier. The median HBB half-life was 12 years (range 4-97 years). The CBT and CMR were elevated in the subjects exposed to PBBs as compared to the values obtained from urban nonsmokers and were similar to those found in adults who smoke. A gender effect was seen in the PBB-exposed subjects. There was a correlation between the CBT and the HBB serum values but not between CMR and HBB serum values. The CBT and CMR were easily conducted in the field and appear to be useful metabolic probes of cytochrome P-450I activity in human environmental toxicology.

OSTI ID:
5840096
Journal Information:
Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 89; ISSN 0091-6765; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANALEPTICS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
BROMINATED AROMATIC HYDROCARBONS
CAFFEINE
CARBON 12
CARBON 13
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON ISOTOPES
CARBON OXIDES
CENTRAL NERVOUS SYSTEM AGENTS
CHALCOGENIDES
CHEMICAL ANALYSIS
CYTOCHROMES
DRUGS
EPIDEMIOLOGY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FEDERAL REGION V
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
HUMAN POPULATIONS
ISOTOPE RATIO
ISOTOPES
LIGHT NUCLEI
MATERIALS
METABOLISM
METABOLITES
MICHIGAN
NORTH AMERICA
NUCLEI
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PIGMENTS
POPULATIONS
PROTEINS
PURINES
QUANTITATIVE CHEMICAL ANALYSIS
STABLE ISOTOPES
URINE
USA
WASTES
XANTHINES