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Serial PBB levels, PCB levels, and clinical chemistries in Michigan's PBB cohort

Journal Article · · Arch. Environ. Health; (United States)
 [1]; ;
  1. U.S. Dept. of Health and Human Services, Atlanta, GA
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Half of a cohort of 3683 Michigan residents exposed to polybrominated biphenyls (PBBs) in 1973 and 1974 had 2 serum PBB determinations at a 1- or 2-yr interval. The median decrease in serum PBB levels during both 1- and 2-yr intervals was 1 ..mu..g/L. The geometric mean serum polychlorinated biphenyl (PCB) level (6.3 ..mu..g/L) exceeded that of PBB (4.1 ..mu../L), although the range of PCB levels (< 1-57 ..mu..g/L) was narrower than that of PBB levels (<1-3150 ..mu..g/L). Mean PCB and PBB levels were higher for mates, and mean PCB levels increased with age. In a subgroup with higher-than-average PBB levels, serial clinical cheimistry tests during 4 different years showed no consistent significant correlation with serum PBB levels. Tests with greater sensitivity and specificity for hepatic microsomal enzyme induction and thyroid status are needed in future evaluations of the most highly exposed subgroup of the cohort.
OSTI ID:
7065102
Journal Information:
Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 37:3; ISSN AEHLA
Country of Publication:
United States
Language:
English

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Related Subjects

552000 -- Public Health
560306* -- Chemicals Metabolism &amp; Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AGE DEPENDENCE
AROMATICS
BIOLOGICAL ACCUMULATION
BLOOD SERUM
BROMINATED AROMATIC HYDROCARBONS
CHLORINATED AROMATIC HYDROCARBONS
CONCENTRATION RATIO
FEDERAL REGION V
HALOGENATED AROMATIC HYDROCARBONS
HUMAN POPULATIONS
MICHIGAN
NORTH AMERICA
ORGANIC BROMINE COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POPULATIONS
SEX DEPENDENCE
USA