Transfusion-associated graft-versus-host disease

Journal Article · Sat Sep 01 04:00:00 EDT 1990 · Yale Journal of Biology and Medicine; (USA)

OSTI ID:5839612

Rappeport, J M ^[1]

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1. Yale Univ. School of Medicine, New Haven, CT (USA)

The clinical pathologic syndrome of graft-versus-host disease (GVHD) is usually a sequela of bone marrow transplantation. This disorder occurs as a result of recognition by engrafted donor-derived lymphocytes of foreign recipient transplantation antigens. GVHD may also result from engraftment of lymphocytes from other sources, including (1) transfusion of lymphocytes containing blood components, (2) transplacental maternal fetal transfusion, and (3) passive transfer of lymphocytes in solid organ transplantation. The recipients are usually severely immunodeficient and thus incapable of rejecting the transfused lymphocytes. This syndrome may, however, also develop in immunologically competent patients receiving blood products from individuals with histocompatibility antigens not recognized as foreign. 58 refs.

• OSTI ID: 5839612
• Journal Information: Yale Journal of Biology and Medicine; (USA), Journal Name: Yale Journal of Biology and Medicine; (USA) Vol. 63:5; ISSN YJBMA; ISSN 0044-0086
• Country of Publication: United States
• Language: English

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560120* -- Radiation Effects on Biochemicals
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
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BLOOD PLATELETS
BODY FLUIDS
BONE MARROW CELLS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GRAFT-HOST REACTION
IMMUNITY
LEUKOCYTES
LYMPHOCYTES
MATERIALS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RISK ASSESSMENT
SOMATIC CELLS
THERAPY
TRANSFUSIONS
TRANSPLANTS
ULTRAVIOLET RADIATION