Chromosomal locations of the human and mouse genes for precursors of epidermal growth factor and the. beta. subunit of nerve growth factor

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.82.2.469· OSTI ID:5836268

Zabel, B U; Eddy, R L; Lalley, P A; Scott, J; Bell, G I; Shows, T B

DNA probes for pre-pro-epidermal growth factor (EGF) and the precursor of the ..beta.. subunit of nerve growth factor (NGF) were used to chromosomally map human and mouse EGF and NGF genes in panels of human-mouse and mouse-Chinese hamster somatic cell hybrids. The EGF and NGF genes were mapped to human chromosomes 4 and 1, respectively, by using human-mouse cell hybrids. A combination of regional mapping using a chromosome 1 translocation and comparative gene mapping suggests that the human NGF gene is in the p21-p22.1 region of chromosome 1. In mouse-Chinese hamster cell hybrids, both genes were assigned to mouse chromosome 3. A knowledge of the chromosomal assignment of these genes should help in our understanding of their regulation and role in development and disease.

• Research Organization: New York State Dept. of Health, Buffalo
• OSTI ID: 5836268
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 82:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
GENETIC MAPPING
EPIDERMIS
GROWTH
NERVE CELLS
DNA
GENES
HAMSTERS
HYBRIDIZATION
MAN
MICE
PRECURSOR
SOMATIC CELLS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
EPITHELIUM
MAMMALS
MAPPING
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RODENTS
SKIN
TISSUES
VERTEBRATES
550400* - Genetics