Ovarian imaging by the binding of radioiodinated chorionic gonadotropin: concise communication. [I-131, rats]

Journal Article · Sat Sep 01 00:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5831392

Lee, C Y; Lee, S L; Loken, M K

Previous studies have demonstrated the presence of specific, high-affinity receptors for human chorionic gonadotropin (HCG) in human and rat ovaries. In the present study, highly purified HCG was labeled with iodine-131 and used for the imaging of luteinized rat ovaries. Excellent images were obtained. The accumulation of radioactivity in the ovaries was completely inhibited by previous administration of excess unlabeled HCG. Time-course studies show that radioiodinated HCG was rapidly accumulated within 1 hr and largely cleared from the ovary at 24 hr. These results show the potential for imaging of endocrine target tissues by hormone-receptor binding, and the possibility of quantitation of hormone receptors in tissues under pathological conditions.

• Research Organization: Univ. of Minnesota, Minneapolis
• OSTI ID: 5831392
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD-PLASMA CLEARANCE
BODY
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
FEMALE GENITALS
GONADOTROPINS
GONADS
HCG
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LH
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RETENTION
RODENTS
SCINTISCANNING
VERTEBRATES