Effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH
Journal Article
·
· Immunopharmacology; (United States)
Experiments were performed to demonstrate that, while the shock-inducing dose of parent (toxic) endotoxin significantly decreases the serum T4 level of rats and inhibits the T4 response given to exogenous thyroid stimulating hormone (TSH), the radio-detoxified (/sup 60/Co-gamma, 150 kGy) endotoxin preparation does not inhibit the response to exogenous TSH. It also decreases serum T4 level to a lesser extent than untreated endotoxin.
- Research Organization:
- Frederic Joliot-Curie National Research Inst. for Radiobiology and Radiohygiene, Budapest, Hungary
- OSTI ID:
- 5826172
- Journal Information:
- Immunopharmacology; (United States), Vol. 8:3-4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ENDOTOXINS
BIOLOGICAL EFFECTS
THYROXINE
BIOCHEMICAL REACTION KINETICS
CELL MEMBRANES
COBALT 60
GAMMA RADIATION
LABELLED COMPOUNDS
RATS
THYROID
TRACER TECHNIQUES
AMINO ACIDS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MATERIALS
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIATIONS
RADIOISOTOPES
REACTION KINETICS
RODENTS
THYROID HORMONES
TOXIC MATERIALS
TOXINS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques
ENDOTOXINS
BIOLOGICAL EFFECTS
THYROXINE
BIOCHEMICAL REACTION KINETICS
CELL MEMBRANES
COBALT 60
GAMMA RADIATION
LABELLED COMPOUNDS
RATS
THYROID
TRACER TECHNIQUES
AMINO ACIDS
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
HORMONES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MATERIALS
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIATIONS
RADIOISOTOPES
REACTION KINETICS
RODENTS
THYROID HORMONES
TOXIC MATERIALS
TOXINS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques