Effects of mixed neutron-. gamma. total-body irradiation on physical activity performance of rhesus monkeys

Journal Article · Fri Mar 01 04:00:00 EST 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576502· OSTI ID:5825645

Franz, C G

Behavioral incapacitation for a physical activity task and its relationship to emesis and survival time following exposure to ionizing radiation were evaluated in 39 male rhesus monkeys (Macaca mulatta). Subjects were trained to perform a shock avoidance activity task for 6 hr on a 10-min work/5-min rest schedule in a nonmotorized physical activity wheel. Following stabilization of performance, each subject received a single, pulsed dose of mixed neutron-..gamma.., whole-body radiation (n/..gamma.. = 3.0) ranging between 1274 and 4862 rad. Performance testing was started 45 sec after exposure. A dose-response function for early transient incapacitation (ETI) during the first 2 hr after irradiation was fitted, and the median effective dose (ED/sub 50/) was calculated to be 1982 rad. Analysis done on the relationship of dose to ETI, emesis, and survival time found (a) a significant relationship between the radiation dose and the number and duration of ETIs; (b) no correlation between emesis and dose, survival time, or ETI; (c) no relation between survival time and ETI at any dose; and (d) no significant difference in survival time for dose groups between 1766 +/- 9 (SEM) and 2308 +/- 23 rad.

• Research Organization: Armed Forces Radiobiology Research Institute, Bethesda, MD
• OSTI ID: 5825645
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 101:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFRRI REACTOR
ANIMALS
AVOIDANCE
BARYONS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DOSIMETRY
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENRICHED URANIUM REACTORS
EXTERNAL IRRADIATION
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
HOMOGENEOUS REACTORS
HYDRIDE MODERATED REACTORS
IONIZING RADIATIONS
IRRADIATION
IRRADIATION REACTORS
ISOTOPE PRODUCTION REACTORS
MAMMALS
MOCKUP
MONKEYS
NEUTRONS
NUCLEONS
PHANTOMS
PRIMATES
RADIATION EFFECTS
RADIATIONS
REACTORS
RESEARCH AND TEST REACTORS
RESEARCH REACTORS
SOLID HOMOGENEOUS REACTORS
STRUCTURAL MODELS
SURVIVAL TIME
SYMPTOMS
THERMAL REACTORS
TRAINING REACTORS
TRIGA TYPE REACTORS
VERTEBRATES
VOMITING
WATER COOLED REACTORS
WATER MODERATED REACTORS
WHOLE-BODY IRRADIATION