Comparison of Xe-133 washout and single-breath imaging for the detection of ventilation abnormalities

Journal Article · Sat Sep 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5825393

Alderson, P O; Lee, H; Summer, W R; Motazedi, A; Wagner, Jr, H N

The Xe-133 ventilation studies of 115 patients were analyzed to determine the relative abilities of the single-breath and washout phases to detect regional ventilation abnormalities. All Xe-133 images were obtained in the posterior projection before 6-view perfusion studies with Tc-99m human albumin microspheres. There were 275 regions with matching V-P abnormalities in the patients. The washout portion of the study detected 258 of these regions (94%) and the single breath detected 175 (64%) (p < 0.01). The discrepancies were confined to regions with nonsegmental perfusion defects, where the single breath detected 139 matches and the washout 216. The discrimination ratio between normal areas and areas of obstructive lung disease improved from 2 to 1 after 1 min of washout to 30 to 1 after 5 min. The late phases of Xe-133 washout are useful in detecting ventilation abnormalities, especially those associated with nonsegmental perfusion defects.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 5825393
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD FLOW
BODY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LUNGS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
XENON 133
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES