Developmental toxicity of four glycol ethers applied cutaneously to rats
Previous NIOSH studies demonstrated the embryo- and fetotoxicity and teratogenicity of ethylene glycol monoethyl ether (EGEE) applied to the shaved skin of pregnant rats. In the present study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol monobutyl ether (EGBE), and diethylene glycol monoethyl ether (diEGEE) were tested in the same experimental model, using distilled water as the negative control and EGEE as a positive control. Water or undiluted glycols were applied four times daily on days 7 to 16 of gestation to the shaved interscapular skin with an automatic pipetter. Volumes of EGEE (0.25 mL), EGEEA (0.35 mL), and diEGEE (0.35 mL) were approximately equimolar (2.6 mmole per treatment). EGBE at 0.35 mL four times daily (approximately 2.7 mmole per treatment) killed 10 of 11 treated rats, and was subsequently tested at 0.12 mL (0.9 mmole) per treatment. EGEE- and EGEEA-treated rats showed a reduction in body weight relative to water controls that was associated with completely resorbed litters and significantly fewer live fetuses per litter. Fetal body weights were also significantly reduced in those groups. Visceral malformations and skeletal variations were significantly increased in EGEE and EGEEA groups over the negative control group. No embryotoxic, genotoxic, or teratogenic effects were detected in the EGBE- or diEGEE-treated litters. 16 references, 4 tables.
- Research Organization:
- National Institute for Occupational Safety and Health, Cincinnati, OH
- OSTI ID:
- 5824683
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 57; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment
Survey of ethylene glycol ether exposures in Belgian industries and workshops
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
BIOLOGICAL MODELS
BODY
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
EMBRYOS
ETHERS
ETHYL ETHER
FETUSES
GLYCOLS
HYDROXY COMPOUNDS
MAMMALS
NATIONAL ORGANIZATIONS
NIOSH
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANCY
RATS
RODENTS
SENSITIVITY
SKIN
TERATOGENESIS
TOXICITY
US ORGANIZATIONS
VERTEBRATES
WEIGHT