Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.845733· OSTI ID:5706035

Doe, J E

An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50, and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. In this study, EGEE was found not to cause teratogenic effects at concentrations up to and including 250 ppm in rats and 50 ppm in rabbits, while 175 ppm EGEE was considered to be a marginal effect level for teratogenic effects in rabbits. Fetotoxicity was observed at 250 ppm EGEE and possibly at 50 ppm EGEE in rats. An inhalation teratology study using ethylene glycol monoethyl ether acetate (EGEEA) has been conducted in rabbits at 25, 100, and 400 ppm. There was evidence of teratogenicity (vertebral malformations) at 400 ppm EGEEA and slight fetotoxicity at 100 ppm; 25 ppm was a no effect level. 12 references, 12 tables.

• Research Organization: Imperial Chemical Industries PLC, Macclesfield, England
• OSTI ID: 5706035
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 57; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ALCOHOLS
ANIMALS
CARBOXYLIC ACID SALTS
DOSE-RESPONSE RELATIONSHIPS
ETHERS
ETHYL ETHER
FETUSES
GLYCOLS
HYDROXY COMPOUNDS
INHALATION
INTAKE
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
RABBITS
RATS
RODENTS
SCREENING
TERATOGEN SCREENING
TERATOGENESIS
TOXICITY
VERTEBRATES