Plasma electrolytes in relation to altitude tolerance in rats

Journal Article · Sat Mar 31 23:00:00 EST 1979 · Aviat., Space Environ. Med.; (United States)

OSTI ID:5822665

Purshottam, T

Plasma concentrations of Na(+), K(+) and Cl(-) ions did not change significantly whereas that of (HCO3)- dropped to one-third of its initial value in rats during their 15 min of gasping at a simulated altitude of 10,000 m at 33 C, which was their survival threshold. Administration of methamphetamine (2 mg/kg), imipramine (2 mg/kg) and adrenaline (7 mg/kg) i.p. were ineffective in prolonging the survival time of rats, whereas acetazolamide (40 mg/kg), furosemide (2 mg/kg) and caffeine citrate (10 mg/kg) significantly increased their survival under hypoxia, (p less than 0.001, 0.01, and 0.05, respectively).

• Research Organization: Defence Research and Development Establishment, Biochemistry Div., Gwalior, India
• OSTI ID: 5822665
• Journal Information: Aviat., Space Environ. Med.; (United States), Journal Name: Aviat., Space Environ. Med.; (United States) Vol. 50; ISSN ASEMC
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ADRENALINE
ALTITUDE
AMPHETAMINES
ANALEPTICS
ANIMALS
ANOXIA
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD PLASMA
BODY FLUIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
ELECTROLYTES
HORMONES
MAMMALS
MATERIALS
NEUROREGULATORS
PSYCHOTROPIC DRUGS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
STEROID HORMONES
SURVIVAL TIME
SYMPATHOMIMETICS
TOLERANCE
VERTEBRATES