An AP-2 element acts synergistically with the cyclic AMP- and Phorbol ester-inducible enhancer of the human proenkephalin gene

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Mol. Cell. Biol.; (United States)

DOI:https://doi.org/10.1128/MCB.9.1.321· OSTI ID:5822289

Hyman, S E; Comb, M; Pearlberg, J; Goodman, H M

An enhancer with two DNA elements, one containing the sequence CGTCA, is required for cyclic AMP-and phorbol ester-inducible transcription of the human proenkephalin gene. The authors report that an AP-2 element located adjacent to the enhancer acts synergistically with it to confer maximal response to cyclic AMP and phorbol esters.

• Research Organization: Molecular Neuropeptides Lab., Neuroscience Center, Massachusetts General Hospital East, Charlestown, MA (US); Massachusetts General Hospital, Boston, MA (USA). Dept. of Molecular Biology
• OSTI ID: 5822289
• Journal Information: Mol. Cell. Biol.; (United States), Vol. 9:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ENKEPHALINS
GENES
GENETIC MAPPING
TRANSCRIPTION
BIOLOGICAL PATHWAYS
AMP
DNA SEQUENCING
GENE REPRESSORS
PHORBOL ESTERS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARCINOGENS
DRUGS
ENDORPHINS
ESTERS
MAPPING
NEUROREGULATORS
NUCLEOPROTEINS
NUCLEOTIDES
ORGANIC COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics
550200 - Biochemistry