Physical map of human Xq27-qter: Localizing the region of the fragile X mutation

Journal Article · Tue Oct 01 04:00:00 EDT 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.19.8302· OSTI ID:5821640

Poustka, A; Dietrich, A; Langenstein, G ^[1]; Toniolo, D ^[2]; Warren, S T ^[3]; Lehrach, H ^[4]

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1. Deutsches Krebsforschungszentrum, Heidelberg (West Germany)
2. Istituto di Genetica Biochemica ed Evoluzionistica, Pavia (Italy)
3. Emory Univ., Atlanta, GA (United States)
4. Imperial Cancer Research Fund, London (England)

The authors describe a physical map of the end of the long arm of the human X chromosome encompassing the region from Xq27.2 to the q telomere, inclusive of the chromosomal band Xq28. This region is of particular interest, since it contains the highest density of genes associated with genetic diseases. The map covers a total of 12 megabases (Mb) of DNA and extends from the telomere to 3 Mb beyond the most likely position of the fragile X mutation, defined by a cluster of translocation breakpoints in somatic cell hybrids. The map determines order and position of loci throughout the Xq28 region and localizes cell line breakpoints marking the fragile X region to an interval of 300-700 kilobases between 8 and 8.7. Mb proximal of the Xq telomere.

• OSTI ID: 5821640
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 88:19; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AZINES
CHROMOSOMES
DISEASES
DNA HYBRIDIZATION
ELECTROPHORESIS
GENE MUTATIONS
GENETIC MAPPING
HEREDITARY DISEASES
HETEROCHROMOSOMES
HETEROCYCLIC COMPOUNDS
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
HYBRIDIZATION
MAPPING
MUTATIONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RIBOSIDES
THYMIDINE
X CHROMOSOME