Potentiation by caffeine of x-ray damage to cultured human skin fibroblasts from normal subjects and ataxia-telangiectasia patients

Journal Article · Fri Jul 01 00:00:00 EDT 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576085· OSTI ID:5816826

Furcinitti, P S

Caffeine was found to potentiate x-ray-induced killing of human diploid fibroblasts from a normal subject and an ataxia-telangiectasia (AT) patient when it was present at 2 mM concentration for 30 to 66 h postirradiation. The dose-modifying factor for caffeine-treated normal cells had an average value of 1.26 +- 0.13 which did not vary significantly with treatment time or x-ray dose. The dose-modifying factor for caffeine-treated AT cells was 1.12 +- 0.12 at 30 h, rose to 1.66 +- 0.17 at 41 h, and decreased to 1.31 +- 0.13 at 66 h. Thus no clear difference was observed between these two cell strains' susceptibility to postirradiation caffeine treatment.

• Research Organization: Columbia Univ. New York, NY
• DOE Contract Number: AC02-78EV04733; AC02-76CH00016
• OSTI ID: 5816826
• Journal Information: Radiat. Res.; (United States), Vol. 95:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CAFFEINE
RADIOSENSITIVITY EFFECTS
CELL KILLING
RADIOINDUCTION
FIBROBLASTS
IN VITRO
MAN
SKIN
TELANGIECTASIS
X RADIATION
ANALEPTICS
ANIMAL CELLS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM AGENTS
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PRIMATES
PURINES
RADIATIONS
SKIN DISEASES
SOMATIC CELLS
VASCULAR DISEASES
VERTEBRATES
XANTHINES
560121* - Radiation Effects on Cells- External Source- (-1987)
560301 - Chemicals Metabolism & Toxicology- Cells- (-1987)