Current status of adrenalectomy for Cushing's disease
To evaluate the current use of adrenalectomy in the treatment of Cushing's disease, we reviewed seven consecutive patients who have undergone adrenalectomy for Cushing's disease at this medical center during 1983 to 1984. Seventy-one percent (5/7) had pituitary, or type I, Cushing's disease, while 29% (2/7) had adrenal, or type II, Cushing's disease from either an adenoma or an adrenocortical carcinoma. Presenting signs and symptoms, either initially or at the time of recurrence, were typical of Cushing's syndrome. Four of five patients with type I disease had recurrent disease after transphenoidal hypophysectomy, bilateral adrenalectomy, or unilateral adrenalectomy. In three of five patients, medical therapy of hypercortisolism was abandoned because of adverse side effects. Preoperative evaluation in all patients included cortisol and ACTH levels, dexamethasone suppression tests, and computerized tomography (both abdominal and head). In patients with a prior history of adrenalectomy, radiocholesterol scans were also performed and were useful. Angiographic procedures were not required in these patients. In patients with type I disease, posterior operative approaches were used. In patients with type II disease, an anterolateral approach was used. Posterolateral incisions are preferred over Hugh-Young incisions and provide better exposure with a reduced risk of poor wound healing. Morbidity and mortality included one death and three nonhealing wounds. In the six surviving patients, symptoms resolved with variable frequency. Findings suggestive of Nelson's syndrome (hyperpigmentation) have occurred in two patients; serial computerized tomographic scans fail to reveal evidence of pituitary tumors.
- OSTI ID:
- 5810142
- Journal Information:
- Surgery; (United States), Vol. 6
- Country of Publication:
- United States
- Language:
- English
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ABDOMEN
EMISSION COMPUTED TOMOGRAPHY
CUSHING SYNDROME
ADRENALECTOMY
HEAD
ADENOMAS
ADRENAL GLANDS
CARCINOMAS
CHOLESTEROL
DEXAMETHASONE
HYDROCORTISONE
MORTALITY
PATIENTS
RADIOISOTOPE SCANNING
ADRENAL HORMONES
BODY
BODY AREAS
COMPUTERIZED TOMOGRAPHY
CORTICOSTEROIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MEDICINE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PREGNANES
STEROID HORMONES
STEROIDS
STEROLS
SURGERY
TOMOGRAPHY
550600* - Medicine
550602 - Medicine- External Radiation in Diagnostics- (1980-)