ADRENAL CORTICAL FUNCTION STUDIES IN CUSHING'S SYNDROME DUE TO NONTUMOROUS ADRENOCORTICAL HYPERFUNCTION TREATED WITH PITUITARY IRRADIATION
The response to Gel-ACTH Metopirone and dexamethamorous adrenocortical hyperfunction with Cushing's syndrome. Four patients were clinically active and 4 were in complete clinical remission. All were treated with pituitary irradiation alone or in combination with unilateral adrenalectomy. After pituitary irradiation, serial studies of 4 subjects with active Cushing's syndrome revealed a progressive decreased hyperresPonsiveness to stimulation with Gel-ACTH; 3 subjects responded in the same way to Metopirone. In 2 patients this occurred within 2 months after the completion of therapy, and in one subject it antedated any overt clinical improvemert. In all 3 subjects in partial clinical remission after pitultary irradiation, the administration of 2 mg of dexamethasone daily for 3 days failed to suppress the urinary excretion of 17- hydroxycorticoids. In 2 of the 4 patients in complete clinical remission, a significant suppression of the urinary excretion of 17-hydroxycorticoids failed to occur following the sa regimen. It appears that dexamethasone suppresswibilty ws the last of the indices of adrenocortical function to return to normal (it may never return to normal in some cases) after the successful treatment of Cushing' s syndrome due to nontumorous adrenocortical hyperfunction. (auth)
- Research Organization:
- Mount Sinai Hospital, New York
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-014525
- OSTI ID:
- 4795321
- Journal Information:
- J. Clin. Endocrinol. and Metabolism, Vol. Vol: 22; Other Information: Orig. Receipt Date: 31-DEC-62
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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