Intraoperative radioimmunodetection of colorectal tumor with a hand-held radiation detector

Journal Article · Sun Dec 01 04:00:00 EST 1985 · Am. J. Surg.; (United States)

DOI:https://doi.org/10.1016/0002-9610(85)90405-2· OSTI ID:5809432

Martin, D T; Hinkle, G H; Tuttle, S; Olsen, J; Nabi, H; Houchens, D; Thurston, M; Martin, Jr, E W

A hand-held gamma detection probe was used intraoperatively to localize primary and recurrent colorectal tumors in 28 patients 48 to 72 hours after they received an intravenous injection of 2.2 mCi of iodine-131 labeled anticarcinoembryonic antigen polyclonal baboon antibody. Preoperative evaluation included determination of serum carcinoembryonic antigen, barium enema, colonoscopy, chest film, computerized axial tomography, liver, spleen, and bone scans, and endoscopy when indicated. Preoperative whole-body imaging correctly localized primary tumors in only 33 percent of the patients, whereas it correctly demonstrated tumor in 64 percent of those with recurrent disease. Intraoperative tumor-to-background ratios derived from the detector probe were elevated in all patients, averaging 3.97:1 in primary lesions and 4.18:1 in recurrent tumors. Postoperatively, carcinoembryonic antigen was localized in tissues with the avidin-biotin peroxidase staining technique to confirm intraoperative readings. Variations in stain uptake in a patient could be correlated with variations in radiation detector readings in the same patient. Results support our previous work in nude mice, demonstrating the improved sensitivity and specificity of the hand-held gamma detection device over whole-body imaging for intraoperative localization of immunoradiolabeled tumors.

• OSTI ID: 5809432
• Journal Information: Am. J. Surg.; (United States), Journal Name: Am. J. Surg.; (United States) Vol. 6; ISSN AJSUA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARCINOEMBRYONIC ANTIGEN
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENZYMES
GASTROINTESTINAL TRACT
GLANDS
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LARGE INTESTINE
LIVER
MEASURING INSTRUMENTS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDOREDUCTASES
PATIENTS
PEROXIDASES
RADIATION DETECTORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SELF-POWERED DETECTORS
SELF-POWERED GAMMA DETECTORS
SKELETON
SPLEEN
TOMOGRAPHY
TRACER TECHNIQUES