Response of the 9L rat brain tumor to combination treatment with radiation and bleomycin

Journal Article · Sat Aug 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90161-9· OSTI ID:5808080

Kimler, B F; Vats, T S; Morantz, R A; Henderson, S D

The therapeutic efficacy of combined modality treatment with radiation therapy and bleomycin was investigated in rats burdened with the intracerebral 9L bliosarcoma. Both radiation (single or fractioned exposures) and bleomycin (injected intracerebrally directly into the tumor region) are effective in prolonging survival when used as single agents. Bleomycin (1.0 mg/kg/week) combined with low-dose radiation therapy (15.3 By in 6 fractions in 2 weeks) prolonged survival over that of radiation alone, but not to the extent of high-dose radiation therapy (30.6 Gy in the same schedule). Bleomycin was effective whether given simultaneously or following fractionated radiation therapy - the important factor being delivery of radiation therapy early in the disease process. The greatest enhancement in survival caused by combination therapy compared to that by single agent therapy was observed when single exposure radiation therapy (20 Gy) followed single bleomycin administration by 4 hr. These results suggest the possibility of using bleomycin as an adjunct to radiation therapy for the treatment of patients with malignant brain tumors.

• Research Organization: Univ. of Kansas Medical Center, Kansas City
• OSTI ID: 5808080
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BLEOMYCIN
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
DRUGS
MAMMALS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIATION DOSES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RATS
RODENTS
SARCOMAS
THERAPY
VERTEBRATES