Comparison of the inhibition of biliary excretion produced by certain inducing agents including 2,3,7,8-tetrachlorodibenzo-p-dioxin
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
Rats were treated with chlordecone, mirex, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and respective solvent vehicle. Under urethane or pentobarbital anesthesia, the bile duct was cannulated and radioactive morphine, imipramine, or ouabain was given by segmented retrograde intrabiliary injection. The spectrum of inhibition of biliary excretion by chlordecone and mirex were similar in that morphine glucuronide and in part polar imipramine metabolite recoveries in bile were decreased; ouabain recovery was unaffected. TCDD was different in that it markedly decreased the recovery of ouabain. Thus, it appears that chlordecone, mirex, and TCDD inhibit the canalicular transport of the glucuronide metabolites of morphine and imipramine into bile, and TCDD affects in addition the canalicular transport of ouabain into bile.
- Research Organization:
- Veterans Administration Medical Center, Milwaukee, WI
- OSTI ID:
- 5800443
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 17:4; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CLP1A1 and CYP1A2
Trans-stilbene oxide administration increased hepatic glucuronidation of morphine but decreased biliary excretion of morphine glucuronide in rats
Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish
Technical Report
·
Tue Dec 31 23:00:00 EST 1991
·
OSTI ID:5441133
Trans-stilbene oxide administration increased hepatic glucuronidation of morphine but decreased biliary excretion of morphine glucuronide in rats
Journal Article
·
Wed Sep 01 00:00:00 EDT 1982
· J. Pharmacol. Exp. Ther.; (United States)
·
OSTI ID:6657521
Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish
Journal Article
·
Sun Jan 31 23:00:00 EST 1988
· Fundam. Appl. Toxicol.; (United States)
·
OSTI ID:7024673
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
AMINES
ANALGESICS
ANIMALS
ANTIDEPRESSANTS
AROMATICS
BILE
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORINATED AROMATIC HYDROCARBONS
DIOXIN
DRUGS
GLYCOSIDES
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
INHIBITION
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
MORPHINE
NARCOTICS
OPIUM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OUABAIN
PSYCHOTROPIC DRUGS
RATS
RETENTION
RODENTS
STROPHANTHINS
TOXICITY
TRACER TECHNIQUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
AMINES
ANALGESICS
ANIMALS
ANTIDEPRESSANTS
AROMATICS
BILE
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOHYDRATES
CARDIAC GLYCOSIDES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHLORINATED AROMATIC HYDROCARBONS
DIOXIN
DRUGS
GLYCOSIDES
HALOGENATED AROMATIC HYDROCARBONS
HETEROCYCLIC COMPOUNDS
IMIPRAMINE
INHIBITION
ISOTOPE APPLICATIONS
MAMMALS
MATERIALS
METABOLISM
METABOLITES
MORPHINE
NARCOTICS
OPIUM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OUABAIN
PSYCHOTROPIC DRUGS
RATS
RETENTION
RODENTS
STROPHANTHINS
TOXICITY
TRACER TECHNIQUES
VERTEBRATES