Enhancement of ozone-induced lung injury by exercise

Journal Article · Tue Jan 01 00:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530792· OSTI ID:5799923

Mautz, W J; McClure, T R; Reischl, P; Phalen, R F; Crocker, T T

Rats were exposed for up to 3.75 h to 0.20-0.80 ppm O/sub 3/ under conditions of rest and treadmill exercise up to 30 m/min, 20% grade, to assess the importance of exposure duration, O/sub 3/ concentration, and exercise on lung tissue injury. Focal lung parenchymal lesions increased in abundance and severity in response to the three variables; however, exercise was the most important. Lesion response to exercise was greater than that predicted by a simple proportion to estimated effective dose of O/sub 3/. The results emphasize the importance of including exercise in assessment of possible adverse health effects of exposure to airborne pollutants.

• Research Organization: Univ. of California, Irvine, CA (United States)
• OSTI ID: 5799923
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 16:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
INJURIES
OZONE
TOXICITY
AIR POLLUTION
ECOLOGICAL CONCENTRATION
EXERCISE
RATS
ANIMALS
BODY
MAMMALS
ORGANS
POLLUTION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)