Lethal and teratogenic effects after exposure to X-rays at various times of early murine gestation

Journal Article · Sat Dec 01 04:00:00 EST 1990 · Teratology; (USA)

DOI:https://doi.org/10.1002/tera.1420420609· OSTI ID:5798153

Mueller, W U.S.; Streffer, C

Various well-defined stages during completion of the second meiotic division and early organogenesis of mouse embryos were X-irradiated with doses of 1-4 Gy (100-400 rad). The major risk was prenatal mortality with radiation sensitivity changing markedly with dependence on the developmental stage irradiated; in the case of day 1 even within hours. The surviving fetuses did show a significantly enhanced frequency of malformations on day 19 of gestation (mostly gastroschisis and some exencephalies). This was true for all stages between days 1 and 8; only sensitivity again changed considerably. The radiation doses used in this study are markedly higher than doses that can be expected from radiation diagnostics, but exposure is in a range comparable to doses that can occur in radiation therapy (e.g., Morbus Hodgkin).

• OSTI ID: 5798153
• Journal Information: Teratology; (USA), Journal Name: Teratology; (USA) Vol. 42:6; ISSN 0040-3709; ISSN TJADA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CELL DIVISION
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
EMBRYOS
IONIZING RADIATIONS
MAMMALS
MICE
MUTATION FREQUENCY
ONTOGENESIS
PREGNANCY
RADIATION DOSES
RADIATIONS
RADIOSENSITIVITY
RODENTS
TERATOGENESIS
VERTEBRATES
X RADIATION