Teratogenicity and embryotoxicity of nickel carbonyl in Syrian hamsters
Nickel carbonyl was administered to groups of pregnant hamsters by inhalation on days 4, 5, 6, 7, or 8 of gestation. The dams were killed on day 15 of gestation, and the fetuses were examined for malformations. Exposure to Ni(CO)/sub 4/ on days 4 or 5 of gestation resulted in malformation in 5.5% and 5.8% of the progeny, respectively. Progeny included 9 fetuses with cystic lungs, 7 fetuses with exencephaly, 1 fetus with exencephaly plus fused rib and 1 fetus with anophthalmia plus cleft palate. Hemorrhages into serious cavities were found. In progeny of dams exposed to Ni(CO)/sub 4/ on days 6 or 7 of gestation, there was 1 fetus with fused ribs and there were 2 fetuses with hydronephrosis. In another experiment, pregnant hamsters were exposed to inhalation of Ni(CO)/sub 4/ on day 5 of gestation; these dams were permitted to deliver their litters and to nurse their pups. There was no significant difference in the average number of live pups in the Ni(CO)/sub 4/-exposed litters compared to control litters. Neonatal mortality was increased in Ni(CO)/sub 4/-exposed litters. This study demonstrates that Ni(CO)/sub 4/ is teratogenic and embryotoxic in Syrian hamsters.
- Research Organization:
- Univ. of Connecticut, Farmington
- OSTI ID:
- 5673594
- Journal Information:
- Teratog., Carcinog., Mutagen.; (United States), Journal Name: Teratog., Carcinog., Mutagen.; (United States) Vol. 1; ISSN TCMUD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CARBONYLS
CENTRAL NERVOUS SYSTEM
CONGENITAL MALFORMATIONS
FETUSES
HAMSTERS
HEMORRHAGE
INHALATION
INTAKE
LITTER SIZE
LUNGS
MALFORMATIONS
MAMMALS
NERVOUS SYSTEM
NICKEL COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PREGNANCY
RESPIRATORY SYSTEM
RODENTS
SYMPTOMS
TERATOGENESIS
TOXICITY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES