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Role of the supX gene in ultraviolet light-induced mutagenesis in Salmonella typhimurium

Journal Article · · J. Bacteriol.; (United States)
OSTI ID:5796881
;
Salmonella typhimurium strains with sup X mutations are more sensitive than wild type to killing by ultraviolet irradiation. Studies with strains bearing the leuD21 mutation revealed that inactivation of the supX locus by a nonsense mutation or a deletion results in a complete lack of ability to produce induced Leu+ reversion mutations after UV irradiation. Suppression of the nonsense supX mutation or the presence of an Escherichia coli K-12 F'-borne supX+ allele restored the capacity for induced reversions and increased cell survival after UV irradiation. Introduction of plasmid pKM101 into supX mutant strains also restored their capacity for UV mutagenesis as well as increased survival. The possible nature of the supX gene product and mechanisms by which it may affect expression of the inducible SOS error-prone repair system are considered.
Research Organization:
Public Health Research Inst., New York, NY
OSTI ID:
5796881
Journal Information:
J. Bacteriol.; (United States), Journal Name: J. Bacteriol.; (United States) Vol. 146:1; ISSN JOBAA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
550400 -- Genetics
560112* -- Radiation Effects on Biochemicals-- In Microorganisms-- (-1987)
560131 -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CELL CONSTITUENTS
DNA
ELECTROMAGNETIC RADIATION
GENE MUTATIONS
GENES
MICROORGANISMS
MUTAGENESIS
MUTATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLASMIDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SALMONELLA
SALMONELLA TYPHIMURIUM
SURVIVAL CURVES
ULTRAVIOLET RADIATION