Establishment of epithelial cell lines following exposure of cultured tracheal epithelium to 12-O-Tetradecanoyl-phorbol-13-acetate
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:5793697
In vitro exposure of rat tracheal epithelium to the tumor-promoting agent 12-O-tetradecanoyl-phorbol-13-acetate results in a marked increase in growth capacity. The growth changes are manifested in an increased rate of cell division and growth in primary cultures and in the establishment of permanent epithelial cell lines. Such changes did not occur in control cultures. Fourteen of the cell lines have been inoculated into immunosuppressed recipients, and all are nontumorigenic.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 5793697
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 38; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Repopulation of denuded tracheal grafts wth normal, preneoplastic, and neoplastic epithelial cell populations
Differentiation of normal and cultured preneoplastic tracheal epithellal cells in rats: importance of epithelial mesenchymal interactions
In vitro development of oncogenicity in cell lines established from tracheal epithelium preexposed in vivo to 7,12-dimethylbenz(a)anthracene
Journal Article
·
Thu Nov 30 23:00:00 EST 1978
· Cancer Res.; (United States)
·
OSTI ID:5884040
Differentiation of normal and cultured preneoplastic tracheal epithellal cells in rats: importance of epithelial mesenchymal interactions
Journal Article
·
Fri Oct 31 23:00:00 EST 1980
· J. Natl. Cancer Inst.; (United States)
·
OSTI ID:6757003
In vitro development of oncogenicity in cell lines established from tracheal epithelium preexposed in vivo to 7,12-dimethylbenz(a)anthracene
Journal Article
·
Sat Jul 01 00:00:00 EDT 1978
· Cancer Res.; (United States)
·
OSTI ID:6040837